Abstract. Microsporum canis is an important agent of dermatophitosis in human and animal. The aim of the current study was to assess the efficacy of ozonized oil over Microsporum canis in rabbits. Eighteen male New Zealand white rabbits were depilated in the cranial dorso-lateral and right caudal, and cranial and left caudal regions. The regions were inoculated with Microsporum canis, excepting the right caudal region, and were denominated TM, O, OM and M. After seven days, the treatment of lesions in TM began with 0.12g of terbinaphine 1cream and in OM and O with ozonized oil; all animals were treated once a day for 28 days. Region M was not treated.

Introduction. The fact that the ozone is a potent oxidant accounts for its high reactivity. Antimicrobial action occurs due to the membrane lysis of the agents, after the oxidation process. It is believed that the primary attack is against the cellular wall of the microorganism and, following, on penetrating the interior of cell, the ozone promotes oxidation of amino and nucleic acids. Cellular lysis depends on the extension of such reactions.

Microsporum canis is worldly distributed and the most common zoophilia species in human infections. Commonly cause tinea capitis and tinea corporis in children and adults who had contact with dogs or cats or infected children. The aim of the present study was to assess the efficacy of the ozonized oil against Microsporum canis in rabbits.

Results. Twenty-eight days after the onset of the treatment, the actions of the terbinaphine cream and the ozonized oil were equivalent.

Discussion. The action of the ozonized oil and terbinaphine cream was similar, the treatment with either therapy brought positive results, since the non-treated regions were all infected by the fungus in the final evaluation at day. Although the areas treated with ozonized oil also showed improvement (Figure 5), it was a slower process if compared with the treatment with terbinaphine.

The mechanism of action of ozone as a fungicidal product seems to be related to the diffusion of ozone through the fungal wall and into the cytoplasm, which breaks the vital cellular function. The cellular wall seems to be a possible site of oxidative inactivation of the ozone.

According to the present study, there is statistical indication that the ozonized oil acts against Microsporum canis, and there is clinical evidence of its action over this dermatophyte.

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